10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the Marine-Derived Fungus Spicaria elegans
- 5 May 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 69 (6), 871-875
- https://doi.org/10.1021/np050201m
Abstract
The three new 10-phenyl-[12]-cytochalasins Z7, Z8, and Z9 (1−3), together with two known analogues, cytochalasins E (4) and K (5), were isolated from the marine-derived fungus Spicaria elegans. This is only the second report to date that cytochalasins contain a 12-membered macrocyclic ring. The structures of the three new cytochalasins were elucidated by spectroscopic methods, and their absolute configurations were determined for the first time by the modified Mosher's method. All five cytochalasins were evaluated for their cytotoxic effects on P388 and A-549 cell lines by the MTT method.Keywords
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