Clinical Features of CMV-Associated Anterior Uveitis
- 27 November 2017
- journal article
- review article
- Published by Informa UK Limited in Ocular Immunology and Inflammation
- Vol. 26 (1), 107-115
- https://doi.org/10.1080/09273948.2017.1394471
Abstract
Cytomegalovirus (CMV) anterior uveitis is the most common ocular manifestation of CMV disease in immunocompetent individuals. It is thought to be due to a local reactivation of latent CMV and is usually unilateral. The acute form presents as Posner-Schlossman Syndrome, a recurrent hypertensive anterior uveitis with few granulomatous keratic precipitates. There are geographic differences in the chronic form of CMV anterior uveitis. Asian patients commonly present as Fuchs Uveitis Syndrome with diffuse stellate keratic precipitates, while the European patients present with a chronic hypertensive anterior uveitis with fewer keratic precipitates that are brown in color and located inferiorly. Characteristic features of CMV anterior uveitis include mild anterior chamber inflammation, elevated intraocular pressure, stromal iris atrophy. Synechiae, macular edema and retinitis are typically absent. CMV disease may also be associated with the development of corneal endotheliitis with a reduced endothelial cell count. Long-term complications include glaucomatous optic neuropathy and cataract formation.Keywords
This publication has 87 references indexed in Scilit:
- Cytomegalovirus (CMV) seroprevalence in Japanese blood donors and high detection frequency of CMV DNA in elderly donorsTransfusion, 2013
- Cytomegalovirus anterior uveitis in immunocompetent individuals following topical prostaglandin analoguesJournal of Ophthalmic Inflammation and Infection, 2013
- Post-phacoemulsification cytomegalovirus corneal endotheliitis diagnosis and managementJRSM Open, 2012
- Long-term results of oral valganciclovir for treatment of anterior segment inflammation secondary to cytomegalovirus infectionClinical Ophthalmology, 2012
- Viral causes of unexplained anterior uveitis in ThailandEye, 2012
- Cytomegalovirus and the eyeEye, 2011
- Incidence of Cytomegalovirus Infection in Shanghai, ChinaClinical and Vaccine Immunology, 2009
- Cytomegalovirus Retinitis After Fluocinolone Acetonide (Retisert™) ImplantAmerican Journal of Ophthalmology, 2007
- National Serosurvey of Cytomegalovirus in AustraliaClinical and Vaccine Immunology, 2006
- Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosisBritish Journal of Ophthalmology, 2006