Cytomegalovirus and the eye
- 16 December 2011
- journal article
- Published by Springer Science and Business Media LLC in Eye
- Vol. 26 (2), 237-240
- https://doi.org/10.1038/eye.2011.327
Abstract
Following primary infection, cytomegalovirus (CMV) establishes latent infection in myeloid progenitor cells and intermittent viral reactivation from activated macrophages or dendritic cells, which is brought under control by strong virus-specific CD4+ T-cell and CD8+ T-cell responses. CMV retinitis characterized by spreading retinal necrosis due to viral cytopathic effect occurs in patients who have impaired T-cell function as a result of transplantation, AIDS, or immuno-suppressive treatment. The diagnosis of CMV retinitis can be confirmed by PCR amplification of viral DNA in aqueous. When administered intravenously, the antiviral drugs Ganciclovir and Foscarnet have modest penetration into the vitreous compared with direct intra-vitreal injection. In randomized trials of HIV-associated CMV retinitis, a Ganciclovir implant was consistently superior to intravenous Ganciclovir in preventing progression of retinitis. CMV is also implicated in two forms of anterior segment disease in immuno-competent adults, namely CMV anterior uveitis and CMV corneal endotheliitis.Keywords
This publication has 7 references indexed in Scilit:
- Cytomegalovirus as an Etiologic Factor in Corneal EndotheliitisOphthalmology, 2008
- Clinical features and outcomes of cytomegalovirus retinitis after transplantationTransplant Infectious Disease, 2007
- Cytomegalovirus as a Cause of Anterior Uveitis in Immunocompetent PatientsOphthalmology, 2007
- A Controlled Trial of Valganciclovir as Induction Therapy for Cytomegalovirus RetinitisNew England Journal of Medicine, 2002
- IMMUNE RECOVERY VITRITIS AND UVEITIS IN AIDSRetina, 2001
- Cytomegalovirus (CMV) Retinitis Activity Is Accurately Reflected by the Presence and Level of CMV DNA in Aqueous Humor and VitreousThe Journal of Infectious Diseases, 1999
- Treatment of Cytomegalovirus Retinitis with a Sustained-Release Ganciclovir ImplantNew England Journal of Medicine, 1997