Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes
- 12 December 2017
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Signaling
- Vol. 10 (509)
- https://doi.org/10.1126/scisignal.aan2392
Abstract
Age-related reduction of the adaptor protein TRAF3 compromises the innate immune response of monocytes from older individuals.Keywords
Funding Information
- National Institutes of Health (award306479, U19 AI089992)
- National Institutes of Health (award339643, T32 AI007019-38)
- National Institutes of Health (award339644, T32 AI055403)
- National Institutes of Health (award339645, K24 AG042489)
- National Institutes of Health (award339647, HHSN272201100019C)
- Howard Hughes Medical Institute (award306478)
- National Institute on Aging (award362220, P30 AG021342 Claude D. Pepper Older Americans Independence Center)
This publication has 53 references indexed in Scilit:
- Early local immune defences in the respiratory tractNature Reviews Immunology, 2016
- Mx1 reveals innate pathways to antiviral resistance and lethal influenza diseaseScience, 2016
- Visualizing the Beta Interferon Response in Mice during Infection with Influenza A Viruses Expressing or Lacking Nonstructural Protein 1Journal of Virology, 2013
- Monocyte recruitment during infection and inflammationNature Reviews Immunology, 2011
- Differential Recruitment of Dendritic Cells and Monocytes to Respiratory Mucosal Sites in Children with Influenza Virus or Respiratory Syncytial Virus InfectionThe Journal of Infectious Diseases, 2008
- CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and MortalityThe Journal of Immunology, 2008
- Lung Macrophages Serve as Obligatory Intermediate between Blood Monocytes and Alveolar MacrophagesThe Journal of Immunology, 2007
- RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-PhosphatesScience, 2006
- Mortality Associated With Influenza and Respiratory Syncytial Virus in the United StatesJAMA, 2003
- Pandemic versus Epidemic Influenza Mortality: A Pattern of Changing Age DistributionThe Journal of Infectious Diseases, 1998