Differential Recruitment of Dendritic Cells and Monocytes to Respiratory Mucosal Sites in Children with Influenza Virus or Respiratory Syncytial Virus Infection
Open Access
- 1 December 2008
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 198 (11), 1667-1676
- https://doi.org/10.1086/593018
Abstract
Background. Influenza virus and respiratory syncytial virus (RSV) are among the most common viruses causing infections of the lower respiratory tract in young children. Although there are important differences in the immunopathogenesis of these 2 viral pathogens, little is known about how they affect antigen-presenting cells in children with acute infections. Methods. To characterize the immune cells that are mobilized to the respiratory tract by influenza virus and RSV, we analyzed nasal wash and blood samples obtained from children hospitalized with acute respiratory infections. Results. Influenza virus and RSV mobilize immune cells, including myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs), to the nasal mucosa. Patients with influenza virus infection had greater numbers of mDCs, pDCs, and monocytes in nasal wash samples than did patients with RSV infection. The frequencies of respiratory tract and blood T cell subsets were not affected by infection with influenza virus or RSV. Monocyte chemoattractant protein-1 concentrations in nasal wash samples were significantly increased in patients with influenza virus infection but not in those with RSV infection. RANTES (regulated on activation, normally T cell expressed and secreted) concentrations were increased only in the blood of patients with influenza virus infection. Conclusions. Infection with influenza virus or RSV mobilizes antigen-presenting cells to the respiratory tract. The differences in antigen-presenting cell numbers and cytokine concentrations suggest that there are distinctive, early immune responses to these 2 viruses.Keywords
This publication has 35 references indexed in Scilit:
- Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003–2004Vaccine, 2007
- Severe Human Lower Respiratory Tract Illness Caused by Respiratory Syncytial Virus and Influenza Virus Is Characterized by the Absence of Pulmonary Cytotoxic Lymphocyte ResponsesThe Journal of Infectious Diseases, 2007
- Human Cytomegalovirus Subverts the Functions of Monocytes, Impairing Chemokine-Mediated Migration and Leukocyte RecruitmentJournal of Virology, 2006
- Dendritic cell function in cytomegalovirus-infected patients with mononucleosisJournal of Leukocyte Biology, 2006
- Human cytomegalovirus inhibits the migration of immature dendritic cells by down-regulating cell-surface CCR1 and CCR5Journal of Leukocyte Biology, 2004
- Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18Journal of Medical Virology, 2004
- A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virusJournal of Medical Virology, 2004
- Replication of respiratory syncytial virus is inhibited in target cells generating nitric oxide in situFrontiers in Bioscience-Landmark, 2003
- Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.JCI Insight, 1994
- The etiology of acute respiratory infections: III. The role of viruses and bacteriaThe Journal of Pediatrics, 1968