Stimulation of de novo methylation following limited proteolysis of mouse ascites DNA methylase
- 14 November 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 163 (2), 194-198
- https://doi.org/10.1016/0014-5793(83)80817-5
Abstract
The ability of mouse Krebs II ascites cell DNA methylase to add methyl groups to native, unmethylated DNA (de novo activity) is stimulated by limited proteolysis. The affinity of the enzyme for DNA is not altered by this treatment but the rate of reaction is increased so that 40% or more of methylatable sites are methylated within 4.5 h. The activation is associated with a decrease in size of the enzyme to 6.2 S.Keywords
This publication has 16 references indexed in Scilit:
- De novo methylation and expression of retroviral genomes during mouse embryogenesisNature, 1982
- De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.Proceedings of the National Academy of Sciences of the United States of America, 1982
- Substrate and sequence specificity of a eukaryotic DNA methylaseNature, 1982
- Dna Methylation in EukaryoteCritical Reviews in Biochemistry, 1982
- Infectivity and methylation of retroviral genomes is correlated with expression in the animalCell, 1981
- Active gene sequences are undermethylated.Proceedings of the National Academy of Sciences of the United States of America, 1981
- 5-Methylcytosine in Eukaryotic DNAScience, 1981
- α-globin-gene switching during the development of chicken embryos: Expression and chromosome structureCell, 1981
- The somatic replication of DNA methylationCell, 1981
- DNA Methylation and Gene FunctionScience, 1980