5-Methylcytosine in Eukaryotic DNA
- 19 June 1981
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4501), 1350-1357
- https://doi.org/10.1126/science.6262918
Abstract
A small portion of the cytosine residues in the DNA of higher eukaryotes as well as in that of many lowe eukaryotes if methylated. The resulting 5-methylcytosine residues occur in specific in the DNA, usually adjacent to guanine residues on the 3' side. This methylation of eukaryotic DNA has been proposed to function in many ways, including control of transcription, maintenance of chromosome structure, repair of DNA, establishment of preferred sites for mutation, oncogenic transformation, and, in certain systems, protection of DNA against enzymatic degradation.Keywords
This publication has 126 references indexed in Scilit:
- 5-Methylcytosine in the DNA of the polytene chromosomes of the dipteraSciara coprophila,Drosophila melanogaster andD. persimilisChromosoma, 1980
- Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNACell, 1980
- DNA methylation and the frequency of CpG in animal DNANucleic Acids Research, 1980
- 5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which resultBiochemical and Biophysical Research Communications, 1979
- Molecular basis of base substitution hotspots in Escherichia coliNature, 1978
- Genetic Recombination: Strand Transfer and Mismatch RepairAnnual Review of Biochemistry, 1978
- Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells In vivo and in vitro methylationJournal of Molecular Biology, 1973
- Methylation of parental and progeny DNA strands in Physarum polycephalumJournal of Molecular Biology, 1973
- The 5‐methylcytosine content of DNA: Tissue specificityJournal of Cellular Physiology, 1971
- The kinetics of DNA methylation in cultures of a mouse adrenal cell lineJournal of Cellular Physiology, 1970