Incidence and Associated Factors of HIV Drug Resistance in Chinese HIV-Infected Patients Receiving Antiretroviral Treatment
Open Access
- 30 April 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (4), e62408
- https://doi.org/10.1371/journal.pone.0062408
Abstract
Background A critical indicator of the future success of highly active antiretroviral therapy (HAART) is the incidence of HIV drug resistance, which has not been studied in China on the national scale. Methods HIV drug resistance baseline survey was conducted in the eight provinces with the largest numbers of patients on HAART in 2009, and a prospective cohort study with 12-month follow-up was completed in 2010. Patients completed an interviewer-administrated questionnaire and provided blood for CD4+ T-lymphocyte count (CD4 count), HIV viral load (VL), and HIV drug resistance genotyping. Factors associated with incidence of HIVDR were identified by Cox regression analysis. Results The overall prevalence of HIV RNA ≥1000 copies/ml and HIVDR at baseline was 12.4% and 5.6%, respectively. Incidence of HIVDR in the one year follow-up was 3.5 per 100 person years. Independently associated factors were started treatment with a didanosine-based regimen, received care at township hospital or village clinic, low baseline CD4 counts, and high baseline VL. Conclusions The incidence of HIVDR in China was higher than that of some developed countries. China urgently needs to provide comprehensive education and training to doctors at village clinics and township hospitals to improve quality community-based care and treatment.Keywords
This publication has 25 references indexed in Scilit:
- HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected PatientsPLOS ONE, 2013
- Virologic outcomes of first-line HAART and associated factors among Chinese patients with HIV in three sentinel antiretroviral treatment sitesTropical Medicine & International Health, 2010
- Early versus Standard Antiretroviral Therapy for HIV-Infected Adults in HaitiThe New England Journal of Medicine, 2010
- The Prevalence of Transmitted Antiretroviral Drug Resistance in Treatment-Naive HIV-Infected Individuals in ChinaJAIDS Journal of Acquired Immune Deficiency Syndromes, 2010
- Predictors of Virologic Failure in HIV‐1–Infected Adults Receiving First‐Line Antiretroviral Therapy in 8 Provinces in ChinaClinical Infectious Diseases, 2010
- Improved Virological Outcomes in British Columbia Concomitant with Decreasing Incidence of HIV Type 1 Drug Resistance DetectionClinical Infectious Diseases, 2010
- Virological efficacy and emergence of drug resistance in adults on antiretroviral treatment in rural TanzaniaBMC Infectious Diseases, 2009
- Effect of Early versus Deferred Antiretroviral Therapy for HIV on SurvivalThe New England Journal of Medicine, 2009
- The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001–2006) in PortugalRetrovirology, 2008
- Web Resources for HIV Type 1 Genotypic-Resistance Test InterpretationClinical Infectious Diseases, 2006