The Prevalence of Transmitted Antiretroviral Drug Resistance in Treatment-Naive HIV-Infected Individuals in China
- 1 February 2010
- journal article
- other
- Published by Ovid Technologies (Wolters Kluwer Health) in JAIDS Journal of Acquired Immune Deficiency Syndromes
- Vol. 53 (Supplement), S10-S14
- https://doi.org/10.1097/qai.0b013e3181c7d363
Abstract
Background: Transmission of HIV drug resistance (TDR) gives rise to reduced efficacy of initial antiretroviral treatment and has become a public health concern. Methods: A nationwide survey on TDR was conducted in antiretroviral therapy-naive HIV-1-infected individuals from September 2004 to October 2005 in China. Drug resistance genotyping was performed on subjects' plasma samples. Drug resistance mutations were determined and scored by Stanford HIV Drug Resistance algorithm. Results: Sequences were obtained from 676 individuals, of whom 61.2% were former plasma and blood donors, 17.3% were infected sexually, and 17.2% were intravenous drug users. Subtype B' HIV-1 strains were found in 73.5%, CRF01_AE in 13.9%, CRF07_BC in 6.2%, CRF08_BC in 2.7%, subtype C in 1.04%, subtype B in 0.9%, CRF02_AG in 0.4%, and B'/C intersubtype recombinant strains in 1.3% of the subjects. Twenty-six (3.8%) were found to harbor drug resistance strains. The rates of resistance to protease inhibitors, nucleoside reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors were 0.4%, 1.6%, and 2.1%, respectively. Though there was no significant difference in TDR rates between 2004 and 2005 (2.9% vs. 4.4%), an increased trend was observed in the rate of high-level drug resistance (0.8% in 2004 vs. 3.0% in 2005, P = 0.0634). Conclusions: The rate of TDR was relatively low in China, as compared with those in developed countries. Surveys among recently HIV-infected subjects should be performed continually to ensure the success of the scale-up antiretroviral treatment.Keywords
This publication has 11 references indexed in Scilit:
- National Survey for Drug-Resistant Variants in Newly Diagnosed Antiretroviral Drug-Naive Patients With HIV/AIDS in South Korea: 1999-2005JAIDS Journal of Acquired Immune Deficiency Syndromes, 2008
- Antiretroviral drug resistance among antiretroviral-naïve persons with recent HIV infection in ThailandHIV Medicine, 2008
- Transmission of drug-resistant HIV-1 in Europe remains limited to single classesAIDS, 2008
- Sex worker incarceration in the People's Republic of ChinaSexually Transmitted Infections, 2008
- The Chinese free antiretroviral treatment program: challenges and responsesAIDS, 2007
- Genetic Diversity and Drug Resistance of Human Immunodeficiency Virus Type 1 (HIV-1) Strains Circulating in ShanghaiAIDS Research and Human Retroviruses, 2007
- Prevalence and determinants of transmitted antiretroviral drug resistance in HIV-1 infectionJournal of Antimicrobial Chemotherapy, 2007
- Genotypic Resistance Mutations to Antiretroviral Drugs in Treatment-Naive HIV/AIDS Patients Living in Liaoning Province, China: Baseline Prevalence And Subtype-Specific DifferenceAIDS Research and Human Retroviruses, 2007
- HIV Type 1polGene Diversity and Antiretroviral Drug Resistance Mutations in the Democratic Republic of Congo (DRC)AIDS Research and Human Retroviruses, 2006
- Current progress of China's free ART programCell Research, 2005