Radial Glial Dependent and Independent Dynamics of Interneuronal Migration in the Developing Cerebral Cortex
Open Access
- 29 August 2007
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 2 (8), e794
- https://doi.org/10.1371/journal.pone.0000794
Abstract
Interneurons originating from the ganglionic eminence migrate tangentially into the developing cerebral wall as they navigate to their distinct positions in the cerebral cortex. Compromised connectivity and differentiation of interneurons are thought to be an underlying cause in the emergence of neurodevelopmental disorders such as schizophrenia. Previously, it was suggested that tangential migration of interneurons occurs in a radial glia independent manner. Here, using simultaneous imaging of genetically defined populations of interneurons and radial glia, we demonstrate that dynamic interactions with radial glia can potentially influence the trajectory of interneuronal migration and thus the positioning of interneurons in cerebral cortex. Furthermore, there is extensive local interneuronal migration in tangential direction opposite to that of pallial orientation (i.e., in a medial to lateral direction from cortex to ganglionic eminence) all across the cerebral wall. This counter migration of interneurons may be essential to locally position interneurons once they invade the developing cerebral wall from the ganglionic eminence. Together, these observations suggest that interactions with radial glial scaffold and localized migration within the expanding cerebral wall may play essential roles in the guidance and placement of interneurons in the developing cerebral cortex.Keywords
This publication has 52 references indexed in Scilit:
- A normal radial glial scaffold is necessary for migration of interneurons during neocortical developmentGlia, 2007
- Multidirectional and multizonal tangential migration of GABAergic interneurons in the developing cerebral cortexDevelopment, 2006
- Generation and characterization of brain lipid‐binding protein promoter‐based transgenic mouse models for the study of radial gliaGlia, 2005
- Nucleokinesis in Tangentially Migrating Neurons Comprises Two Alternating Phases: Forward Migration of the Golgi/Centrosome Associated with Centrosome Splitting and Myosin Contraction at the RearJournal of Neuroscience, 2005
- α3β1 integrin modulates neuronal migration and placement during early stages of cerebral cortical developmentDevelopment, 2004
- Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrainNature Neuroscience, 2004
- Polarized Increase of Calcium and Nucleokinesis in Tangentially Migrating NeuronsCerebral Cortex, 2004
- Radial glia diversity: A matter of cell fateGlia, 2003
- Ventricle-directed migration in the developing cerebral cortexNature Neuroscience, 2002
- Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1Journal of Comparative Neurology, 2000