Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata
Open Access
- 1 December 2011
- journal article
- Published by Oxford University Press (OUP) in The American Journal of Clinical Nutrition
- Vol. 94 (6), 1620-1631
- https://doi.org/10.3945/ajcn.111.016600
Abstract
Background: US black women have higher rates of uterine leiomyomata (UL) and lower intakes of fruit and vegetables than do white women. Whether fruit and vegetable intake is associated with UL in black women has not been studied. Objective: We assessed the association of dietary intake of fruit, vegetables, carotenoids, folate, fiber, and vitamins A, C, and E with UL in the Black Women's Health Study. Design: In this prospective cohort study, we followed 22,583 premenopausal women for incident UL (1997–2009). Diet was estimated by using food-frequency questionnaires in 1995 and 2001. Cox regression was used to derive incidence rate ratios (IRRs) and 95% CIs for the association between each dietary variable (in quintiles) and UL. Results: There were 6627 incident cases of UL diagnosed by ultrasonography (n = 4346) or surgery (n = 2281). Fruit and vegetable intake was inversely associated with UL (≥4 compared with P-trend = 0.03). The association was stronger for fruit (≥2 servings/d compared with P-trend = 0.07) than for vegetables (≥2 servings/d compared with P-trend = 0.51). Citrus fruit intake was inversely associated with UL (≥3 servings/wk compared with P-trend = 0.01). The inverse association for dietary vitamin A (upper compared with lower quintiles: IRR: 0.89; 95% CI: 0.83, 0.97; P-trend = 0.01) appeared to be driven by preformed vitamin A (animal sources), not provitamin A (fruit and vegetable sources). UL was not materially associated with dietary intake of vitamins C and E, folate, fiber, or any of the carotenoids, including lycopene. Conclusion: These data suggest a reduced risk of UL among women with a greater dietary intake of fruit and preformed vitamin A.This publication has 88 references indexed in Scilit:
- A Prospective Study of Dairy Intake and Risk of Uterine LeiomyomataAmerican Journal of Epidemiology, 2009
- Citrus fruit and cancer risk in a network of case–control studiesCancer Causes & Control, 2009
- Prospective study of the association between grapefruit intake and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)Cancer Causes & Control, 2009
- Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cellsClinical Endocrinology, 2008
- Lycopene and other carotenoid intake in relation to risk of uterine leiomyomataAmerican Journal of Obstetrics and Gynecology, 2008
- A prospective study of grapefruit and grapefruit juice intake and breast cancer riskBritish Journal of Cancer, 2007
- Prospective study of grapefruit intake and risk of breast cancer in postmenopausal women: the Multiethnic Cohort StudyBritish Journal of Cancer, 2007
- Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposureFertility and Sterility, 2007
- Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juicesNutrition and Cancer, 1996
- Altered estrogen metabolism and excretion in humans following consumption of indole‐3‐carbinolNutrition and Cancer, 1991