A Prospective Study of Dairy Intake and Risk of Uterine Leiomyomata
Open Access
- 2 December 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 171 (2), 221-232
- https://doi.org/10.1093/aje/kwp355
Abstract
Rates of uterine leiomyomata are 2–3 times higher among black women than white women. Dietary factors that differ in prevalence between these populations that could contribute to the disparity include dairy intake. During 1997–2007, the authors followed 22,120 premenopausal US Black Women's Health Study participants to assess dairy intake in relation to uterine leiomyomata risk. Because soy may be substituted for dairy, the effect of soy intake was also evaluated. Diet was estimated by using food frequency questionnaires in 1995 and 2001. Incidence rate ratios and 95% confidence intervals were estimated with Cox regression. There were 5,871 incident cases of uterine leiomyomata diagnosed by ultrasound (n = 3,964) or surgery (n = 1,907). Multivariable incidence rate ratios comparing 1, 2, 3, and ≥4 servings/day with P-trend <0.001). Incidence rate ratios comparing the highest (≥2 servings/day) with the lowest (<1 serving/week) intake categories were 0.81 (95% CI: 0.66, 0.99) for high-fat dairy, 0.80 (95% CI: 0.70, 0.91) for low-fat dairy, and 0.78 (95% CI: 0.68, 0.89) for milk. Soy intake was unrelated to uterine leiomyomata risk. This large prospective study of black women provides the first epidemiologic evidence of reduced uterine leiomyomata risk associated with dairy consumption.Keywords
This publication has 69 references indexed in Scilit:
- Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohortThe American Journal of Clinical Nutrition, 2009
- Deficiency of sunlight and vitamin DBMJ, 2008
- Lycopene and other carotenoid intake in relation to risk of uterine leiomyomataAmerican Journal of Obstetrics and Gynecology, 2008
- Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentrationHuman Reproduction, 2007
- Consumption of animal foods and endometrial cancer risk: a systematic literature review and meta-analysisCancer Causes & Control, 2007
- The epidemiology of vitamin D and cancer incidence and mortality: A review (United States)Cancer Causes & Control, 2005
- Diet and uterine myomasObstetrics & Gynecology, 1999
- Phytoestrogen content of foods—a compendium of literature valuesNutrition and Cancer, 1996
- Prevalence of lactose maldigestionDigestive Diseases and Sciences, 1994
- Biology of Uterine Myomas and MyometriumIn VitroSeminars in Reproductive Medicine, 1992