Targeting α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors in epilepsy
- 6 January 2014
- journal article
- review article
- Published by Informa Healthcare in Emerging Therapeutic Targets
- Vol. 18 (3), 319-334
- https://doi.org/10.1517/14728222.2014.874416
Abstract
Despite epilepsies being between the oldest and most studied neurological diseases, new treatment remains an unmet need of scientific research due to the high percentage of refractory patients. Several studies have identified new suitable anti-seizure targets. Glutamate activation of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs) have long ago been identified as suitable targets for the development of anti seizure drugs.Keywords
This publication has 100 references indexed in Scilit:
- Calcium‐permeable AMPA receptors are expressed in a rodent model of status epilepticusAnnals of Neurology, 2012
- Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten diseaseNeuropharmacology, 2011
- X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptorNature, 2009
- Regioselective Domino Metathesis of Unsymmetrical 7‐Oxanorbornenes with Electron‐Rich Vinyl Acetate toward Biologically Active Glutamate AnaloguesEuropean Journal of Organic Chemistry, 2009
- Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic ApproachNeuron, 2009
- Regioselective Domino Metathesis of 7‐Oxanorbornenes and Its Application to the Synthesis of Biologically Active Glutamate AnaloguesEuropean Journal of Organic Chemistry, 2008
- Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4Human Molecular Genetics, 2008
- Neuroprotective and anticonvulsant effects of EGIS-8332, a non-competitive AMPA receptor antagonist, in a range of animal modelsBritish Journal of Pharmacology, 2007
- The new 2,3-benzodiazepine derivative EGIS-8332 inhibits AMPA/kainate ion channels and cell deathNeurochemistry International, 2007
- Molecular Targets for Antiepileptic Drug DevelopmentNeurotherapeutics, 2007