Regioselective Domino Metathesis of 7‐Oxanorbornenes and Its Application to the Synthesis of Biologically Active Glutamate Analogues
- 16 October 2008
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2008 (31), 5215-5220
- https://doi.org/10.1002/ejoc.200800704
Abstract
A highly regioselective domino metathesis reaction of 7‐oxanorbornene was developed that employed an intramolecular association of an amide carbonyl group to a ruthenium metal centre. By using this reaction, twelve glutamate analogues inspired by dysiherbaine were efficiently synthesized over 12–14 steps; one of the analogues exhibited bioactivity consistent with central nervous system depression.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)Keywords
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