Dibenzocyclooctadiene Lignans with Antineurodegenerative Potential from Kadsura ananosma
- 7 March 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 74 (5), 1028-1035
- https://doi.org/10.1021/np1009288
Abstract
Fourteen new dibenzocyclooctadiene lignans, ananolignans A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ananosma. The structures and absolute configurations of 1-14 were established using a combination of spectroscopic methods including 1D- and 2D-NMR and CD techniques. The biological activity of the isolated lignans was evaluated, and ananolignan F (6) and ananolignan L (12) showed significant neuroprotective effects in an in vitro assay.Keywords
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