Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis
- 4 May 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 72 (6), 1133-1141
- https://doi.org/10.1021/np900123z
Abstract
Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 microM and a therapeutic index (TI) of more than 25.Keywords
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