Structure and function of mammalian cilia
Open Access
- 26 March 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Histochemistry and Cell Biology
- Vol. 129 (6), 687-693
- https://doi.org/10.1007/s00418-008-0416-9
Abstract
In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease.Keywords
This publication has 53 references indexed in Scilit:
- Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machineryThe Journal of cell biology, 2008
- Mutations inHydinimpair ciliary motility in miceThe Journal of cell biology, 2008
- A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1Nature Medicine, 2007
- Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney DiseaseCurrent Biology, 2007
- A Ciliary Signaling SwitchScience, 2007
- Patched1 Regulates Hedgehog Signaling at the Primary CiliumScience, 2007
- Chlamydomonas reinhardtiihydin is a central pair protein required for flagellar motilityThe Journal of cell biology, 2007
- The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growthThe Journal of cell biology, 2006
- Intraflagellar transportNature Reviews Molecular Cell Biology, 2002
- THE RELATIONSHIP OF CILIA WITH CELL DIVISION AND DIFFERENTIATIONThe Journal of cell biology, 1971