A Ciliary Signaling Switch
- 20 July 2007
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 317 (5836), 330-331
- https://doi.org/10.1126/science.1146180
Abstract
Primary cilia contain the receptor for a secreted protein crucial for cell regulation, strengthening their potential as signaling centers in the cell.Keywords
This publication has 12 references indexed in Scilit:
- Patched1 Regulates Hedgehog Signaling at the Primary CiliumScience, 2007
- The Graded Response to Sonic Hedgehog Depends on Cilia ArchitectureDevelopmental Cell, 2007
- Cholesterol Sensing, Trafficking, and EsterificationAnnual Review of Cell and Developmental Biology, 2006
- Intraflagellar Transport and Cilium-Based SignalingCell, 2006
- Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and FunctionPLoS Genetics, 2005
- Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of GliDevelopmental Biology, 2005
- Vertebrate Smoothened functions at the primary ciliumNature, 2005
- FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determinationNature, 2005
- Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathwaysNature Genetics, 2005
- Intraflagellar transportNature Reviews Molecular Cell Biology, 2002