Enzyme‐Triggered Disassembly of Perylene Monoimide‐based Nanoclusters for Activatable and Deep Photodynamic Therapy
Top Cited Papers
- 3 May 2020
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 59 (33), 14014-14018
- https://doi.org/10.1002/anie.202001107
Abstract
Photodynamic therapy (PDT) exhibits great potential for cancer therapy, but still suffers from nonspecific photosensitivity and poor penetration of photosensitizer. Here, a smart perylene monoimide‐based nanocluster with enzyme‐triggered disassembly is reported as an activatable and deeply penetrable photosensitizer. A novel carboxylesterase (CE)‐responsive tetrachloroperylene monoimide (P1) was synthesized and assembled with folate‐decorated albumins into a nanocluster ( FHP ) with a diameter of ~100 nm. Once P1 is hydrolyzed by the tumor‐specific CE, FHP disassembles into ultrasmall nanoparticles (~10 nm), facilitating the deep tumor penetration of FHP . Furthermore, such enzyme‐triggered disassembly of FHP leads to enhanced fluorescence intensity (~8‐fold) and elevated singlet oxygen generation ability (~4‐fold), enabling in situ near‐infrared fluorescence imaging and promoted PDT. FHP permits remarkable tumor inhibition in vivo with minimal side effects through imaging‐guided, activatable, and deep PDT. This work confirms that this cascaded multifunctional control via enzyme‐triggered molecular disassembly is an effective strategy for precise cancer theranostics.Keywords
Funding Information
- Natural Science Foundation of Beijing Municipality (2202043)
- National Natural Science Foundation of China (21774007, 51903014)
This publication has 52 references indexed in Scilit:
- Investigating the optimal size of anticancer nanomedicineProceedings of the National Academy of Sciences of the United States of America, 2014
- Silica-based nanocapsules: synthesis, structure control and biomedical applicationsChemical Society Reviews, 2014
- Functional Nanomaterials for Phototherapies of CancerChemical Reviews, 2014
- Stimuli‐Responsive Materials for Controlled Release of Theranostic AgentsAdvanced Functional Materials, 2014
- Enzyme-Responsive Amphiphilic PEG-Dendron Hybrids and Their Assembly into Smart Micellar NanocarriersJournal of the American Chemical Society, 2014
- Self-Assembly, Dynamics, and Phase Transformation Kinetics of Donor−Acceptor Substituted Perylene DerivativesJournal of the American Chemical Society, 2010
- Efficient Regio- and Stereoselective Formation of Azocan-2-ones via 8-Endo Cyclization of α-Carbamoyl RadicalsJournal of the American Chemical Society, 2010
- Enzyme-Triggered Disassembly of Dendrimer-Based Amphiphilic NanocontainersJournal of the American Chemical Society, 2009
- Rainbow Perylene Monoimides: Easy Control of Optical PropertiesChemistry – A European Journal, 2009
- Photodynamic therapy for cancerNature Reviews Cancer, 2003