Enzyme-Triggered Disassembly of Dendrimer-Based Amphiphilic Nanocontainers
- 16 September 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 131 (40), 14184-14185
- https://doi.org/10.1021/ja906162u
Abstract
We demonstrate a new enzyme-induced disassembly of amphiphilic nanocontainers based on dendrimers. Disassembly and the ensuing release of noncovalently bound guest molecules are of great interest because of their implications in areas such as drug delivery and sensing. Achieving these with a protein as the stimulus is of even greater importance, because proteins are the primary indicators of biological imbalances. We achieved disassembly of the nanocontainers by disturbing the hydrophilic−lipophilic balance in the amphiphilic dendrimer building blocks.Keywords
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