Neuropharmacological properties of Mikania scandens (L.) Willd. (Asteraceae)
Open Access
- 1 January 2011
- journal article
- research article
- Published by Medknow in Journal of Advanced Pharmaceutical Technology & Research
- Vol. 2 (4), 255-259
- https://doi.org/10.4103/2231-4040.90883
Abstract
Mikania scandens (L.) Willd. (Asteraceae), known as climbing hemp weed in English, is a herbaceous climbing vine grown as a weed throughout the plains of the Indian subcontinent. The present study evaluated some neuropharmacological properties of hydroalcoholic extract of aerial parts from M. scandens (HAMS) in experimental animal models. HAMS (at 250 and 500 mg/kg body weight, i.p.) was evaluated for central antinociceptive activity by tail flick method. Locomotor depressant activity was measured by means of an actophotometer. Skeletal muscle relaxant effect was evaluated by using rotarod apparatus and sedative potentiating property by phenobarbitone-induced sleep potentiation study. The results of the present study revealed significant (PM. scandens possessed prominent depressant action on the CNS, as manifested by the important neuropharmacological properties in mice.Keywords
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