Experimental methods for evaluation of psychotropic agents in rodents: I--Anti-anxiety agents.

Abstract

Rodent models of clinical anxiety are extensively used for evaluating putative anxiolytic activity. In the present review, the available methods which can be utilized by most laboratories, have been discussed. These methods have been categorized as methods involving conditioning techniques and those not involving conditioning. In most cases, the methodology has been briefly discussed in terms of experimental use and efficacy of benzodiazepine and the newer non-benzodiazepine anxiolytics.