The Effects of Intravenous Vitamin C on Point-of-Care Glucose Monitoring
- 1 January 2015
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Burn Care & Research
- Vol. 36 (1), 50-56
- https://doi.org/10.1097/bcr.0000000000000142
Abstract
Ascorbic acid (vitamin C) decreases systemic inflammation and lowers fluid requirements after thermal injury; therefore it has been adopted in many burn centers as an adjunct to resuscitation. However, recent concerns have been expressed over clinically significant hypoglycemic events caused by vitamin C interference with the point-of-care (POC) glucose measurements. This case series presents a direct comparison of POC and laboratory reference glucose values in the patients receiving vitamin C infusion. Vitamin C was administered at 66 mg/kg/hour in seven patients with burns >30% TBSA. The baseline characteristics and burn characteristics were recorded. POC glucose measurements were made with a commonly used hand-held device, and the laboratory values were obtained using standard spectrophotometric methods. POC and laboratory glucose values drawn within the same hour were compared. Hemoglobin, which is known to cause interference in POC testing, was also recorded. All the patients demonstrated falsely elevated POC glucose values during and/or immediately after the infusion period, with discrepancies ranging from 10 to 200 mg/dl. These findings were irregular, unpredictable and unrelated to hemoglobin levels. The findings suggest an idiosyncratic reaction that cannot be easily corrected at the bedside using mathematical equations. POC glucose monitoring should be avoided during and after vitamin C therapy.Keywords
This publication has 26 references indexed in Scilit:
- Increasing Blood Glucose Variability Is a Precursor of Sepsis and Mortality in Burned PatientsPLOS ONE, 2012
- Resuscitation After Severe Burn Injury Using High-Dose Ascorbic Acid: A Retrospective ReviewJournal of Burn Care & Research, 2011
- High-Dose Vitamin C Treatment Reduces Capillary Leakage After Burn Plasma Transfer in RatsJournal of Burn Care & Research, 2010
- Anemia causes hypoglycemia in intensive care unit patients due to error in single-channel glucometers: Methods of reducing patient risk*Critical Care Medicine, 2010
- Glucose Variability is Associated With High Mortality After Severe BurnThe Journal of Trauma and Acute Care Surgery, 2009
- Intensive versus Conventional Glucose Control in Critically Ill PatientsThe New England Journal of Medicine, 2009
- Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients*Critical Care Medicine, 2007
- Safe and Successful Restriction of Transfusion in Burn PatientsJournal of Burn Care & Research, 2006
- Effects of Drugs on Glucose Measurements With Handheld Glucose Meters and a Portable Glucose AnalyzerAmerican Journal of Clinical Pathology, 2000
- Evaluating in vitro and in vivo the interference of ascorbate and acetaminophen on glucose detection by a needle-type glucose sensorBiosensors and Bioelectronics, 1992