Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila
Open Access
- 11 January 2010
- journal article
- Published by Wiley in Aging Cell
- Vol. 9 (1), 100-103
- https://doi.org/10.1111/j.1474-9726.2009.00537.x
Abstract
Studies in a broad spectrum of model organisms have reported that dietary restriction (DR) is associated with an increase in mitochondrial electron transport chain (ETC) function. However, the question of whether ETC function is required for DR-mediated longevity remains controversial. Here, we report that genetic and pharmacological interventions that target mitochondrial complex V affect Drosophila lifespan in a nutrient-dependent manner. These findings support a requirement for mitochondrial complex V in DR-mediated longevity in flies.Keywords
This publication has 21 references indexed in Scilit:
- 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in DrosophilaCell, 2009
- Sod2 knockdown in the musculature has whole-organism consequences in DrosophilaFree Radical Biology & Medicine, 2009
- Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOSScience, 2005
- Rates of Behavior and Aging Specified by Mitochondrial Function During DevelopmentScience, 2002
- A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevityNature Genetics, 2002
- Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respirationNature, 2002
- Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegansDevelopmental Cell, 2001
- A conditional tissue-specific transgene expression system using inducible GAL4Proceedings of the National Academy of Sciences, 2001
- P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogasterProceedings of the National Academy of Sciences, 2001
- A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodesNature, 1998