Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Top Cited Papers
- 1 July 2002
- journal article
- letter
- Published by Springer Science and Business Media LLC in Nature
- Vol. 418 (6895), 344-348
- https://doi.org/10.1038/nature00829
Abstract
Calorie restriction (CR) extends lifespan in a wide spectrum of organisms and is the only regimen known to lengthen the lifespan of mammals1,2,3,4. We established a model of CR in budding yeast Saccharomyces cerevisiae. In this system, lifespan can be extended by limiting glucose or by reducing the activity of the glucose-sensing cyclic-AMP-dependent kinase (PKA)5. Lifespan extension in a mutant with reduced PKA activity requires Sir2 and NAD (nicotinamide adenine dinucleotide)5. In this study we explore how CR activates Sir2 to extend lifespan. Here we show that the shunting of carbon metabolism toward the mitochondrial tricarboxylic acid cycle and the concomitant increase in respiration play a central part in this process. We discuss how this metabolic strategy may apply to CR in animals.This publication has 25 references indexed in Scilit:
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