Trends in Incidence Rates during 1999-2008 and Prevalence in 2008 of Childhood Type 1 Diabetes Mellitus in GERMANY – Model-Based National Estimates
Open Access
- 16 July 2015
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 10 (7), e0132716
- https://doi.org/10.1371/journal.pone.0132716
Abstract
To estimate the national incidence rate and trend of type 1 diabetes (T1DM) in Germany from 1999 to 2008 and the national prevalence in 2008 in the age group 0–14 years. Data were taken from a nationwide registry for incident cases of T1DM in the ages 0–4 years and 3 regional registries (North-Rhine-Westphalia, Baden-Wuerttemberg and Saxony) for incident cases of T1DM in the ages 0–14 years covering 41% of the child population in Germany. The degree of ascertainment was ≥ 97% in all registries. Incident and prevalent cases were grouped by region, sex, age (0–4, 5–9, 10–14 years), and, for incident data, additionally by two 5-year periods (1999–2003, 2004–2008). Poisson regression models were fitted to the data to derive national estimates of incidence rate trends and prevalence in the age groups 5–9, 10–14 and 0–14 years. We used direct age-standardization. The estimated national incidence rate in 0-14-year-olds increased significantly by 18.1% (95%CI: 11.6–25.0%, p<0.001) from 1999–2003 to 2004–2008, independent of sex, corresponding to an average annual increase of 3.4% (95%-CI: 2.2–4.6%). The overall incidence rate was estimated at 22.9 per 100,000 person-years and we identified a within-country west-east-gradient previously unknown. The national prevalence in the ages 0–14 years on 31/12/2008 was estimated to be 148.1 per 100,000 persons. The national incidence rate of childhood T1DM in Germany is higher than in many other countries around the world. Importantly, the estimated trend of the incidence rate confirms the international data of a global increase of T1DM incidences.This publication has 24 references indexed in Scilit:
- Environmental Triggers of Type 1 DiabetesCold Spring Harbor Perspectives in Medicine, 2012
- Improved Metabolic Control in Children and Adolescents With Type 1 DiabetesDiabetes Care, 2011
- Declining prevalence rates for overweight and obesity in German children starting schoolEuropean Journal of Pediatrics, 2011
- Age-specific stabilization in obesity prevalence in German children: A cross-sectional study from 1999 to 2008Pediatric Obesity, 2011
- Thirty Years of Prospective Nationwide Incidence of Childhood Type 1 DiabetesDiabetes, 2011
- Age-Period-Cohort Analysis of 1990–2003 Incidence Time Trends of Childhood Diabetes in ItalyDiabetes, 2010
- Incidence of Childhood Diabetes in Children Aged Less than 15 Years and Its Clinical and Metabolic Characteristics at the Time of Diagnosis: Data from the Childhood Diabetes Registry of Saxony, GermanyHormone Research in Paediatrics, 2010
- Epidemiological Perspectives on Type 1 Diabetes in Childhood and Adolescence in GermanyDiabetes Care, 2009
- Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration studyThe Lancet, 2009
- Incidence of diabetes mellitus among children of Italian migrants substantiates the role of genetic factors in the pathogenesis of type 1 diabetesEuropean Journal of Pediatrics, 2008