Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds
- 23 September 2011
- book chapter
- review article
- Published by Springer Science and Business Media LLC in Advances in experimental medicine and biology
- Vol. 946, 55-68
- https://doi.org/10.1007/978-1-4614-0106-3_4
Abstract
Microbes colonizing and/or infecting chronic wounds undoubtedly play a major and interactive role in impaired healing, especially in amplifying and perpetuating the host innate immune response. The development of molecular techniques to identify and quantify microbial organisms has revolutionized our view of the microbial world. These less-biased, high throughput methods greatly enable investigations regarding host–microbe interactions in the chronic wound environment. This review focuses on the mounting evidence implicating microbes and excessive inflammation in chronic wounds, as well as the challenges associated with understanding how microbes modulate wound healing and the innate immune response.Keywords
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