Defending the end zone: Studying the players involved in protecting chromosome ends
Open Access
- 18 June 2010
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (17), 3773-3778
- https://doi.org/10.1016/j.febslet.2010.06.016
Abstract
The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the “end zone” of chromosomes. Besides having specialized sequences and structures, there are six resident proteins at telomeres that play prominent roles in protecting chromosome ends. In this review, we discuss this team of proteins, termed shelterin, and how it is involved in regulating DNA damage signaling, repair and replication at telomeres.Keywords
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