Increased hepatocarcinogenic potential of hepatitis B virus genotype A in Bantu‐speaking sub‐saharan Africans
- 15 February 2005
- journal article
- Published by Wiley in Journal of Medical Virology
- Vol. 75 (4), 513-521
- https://doi.org/10.1002/jmv.20311
Abstract
Genotypes A, D, and E of the hepatitis B virus (HBV) circulate in southern Africa, with genotype A predominating. Their hepatocarcinogenic potential in Bantu‐speaking sub‐saharan Africans is, however, unknown. Using a case/control format, we investigated the hepatocarcinogenic potential of these genotypes and subgenotype A1 of genotype A, which accounts for the great majority of genotype A isolates. HBV isolates from 111 unselected Bantu‐speaking sub‐saharan Africans with hepatocellular carcinoma (HCC) and 111 matched asymptomatic chronic carriers, serving as controls, were genotyped using the method of [Lindh et al. (1997): J Infect Dis 175:1285–1293]. Subgenotypes of genotype A were determined using an in‐house restriction fragment length polymorphism assay. Genotype A was present in 96 (86.5%) of patients with HCC and 76 (68.5%) of the carriers, giving a 4.5‐fold (95% confidence limits: 1.86, 10.90) increased risk of HCC in carriers infected with genotype A compared with those infected with non‐A genotypes. HCC patients infected with genotype A were significantly younger than those infected with non‐A genotypes (P = 0.02). The distributions between these two groups according to sex, geographic background, and tribe were not significantly different. Subgenotype A1 was present in all of the 77 cancer patients and 69 of 70 carriers analyzed, yielding a relative risk of 4.21 (95% confidence limits: 1.73,10.23) of HCC in those infected with subgenotype A1 compared with those infected with non‐A genotypes. Genotype A has a greater hepatocarcinogenic potential than non‐A genotypes in Bantu‐speaking sub‐saharan Africans and this is entirely attributable to subgenotype A1. J. Med. Virol. 75:513–521, 2005.Keywords
This publication has 41 references indexed in Scilit:
- Hepatitis B Virus Genotype C Takes a More Aggressive Disease Course Than Hepatitis B Virus Genotype B in Hepatitis B e Antigen-Positive PatientsJournal of Clinical Microbiology, 2003
- Detection and significance of a G1862T variant of hepatitis B virus in Chinese patients with fulminant hepatitisJournal of General Virology, 2002
- Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central AmericaJournal of General Virology, 2002
- Analysis of the complete genome of subgroup A′ hepatitis B virus isolates from South AfricaJournal of General Virology, 2002
- Molecular Modeling and Biochemical Characterization Reveal the Mechanism of Hepatitis B Virus Polymerase Resistance to Lamivudine (3TC) and Emtricitabine (FTC)Journal of Virology, 2001
- A new genotype of hepatitis B virus: complete genome and phylogenetic relatednessMicrobiology, 2000
- Hepatitis B virus genomes from long-term immunosuppressed virus carriers are modified by specific mutations in several regionsJournal of General Virology, 1999
- High prevalence of 1762T 1764A mutations in the basic core promoter of hepatitis B virus isolated from black africans with hepatocellular carcinoma compared with asymptomatic carriersHepatology, 1999
- A unique segment of the hepatitis B virus group A genotype identified in isolates from South Africa.Journal of General Virology, 1997
- Genotype F prevails in HBV infected patients of Hispanic origin in Central America and may carry the precore stop mutantJournal of Medical Virology, 1997