Hepatitis B Virus Genotype C Takes a More Aggressive Disease Course Than Hepatitis B Virus Genotype B in Hepatitis B e Antigen-Positive Patients
Open Access
- 1 March 2003
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 41 (3), 1277-1279
- https://doi.org/10.1128/jcm.41.3.1277-1279.2003
Abstract
One hundred forty-six hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients were followed up for 32 ± 13 months. All six patients with hepatocellular carcinoma had hepatitis B virus (HBV) genotype C. Disease activity was greater in patients infected by HBV genotype C than in those infected by HBV genotype B in the HBeAg-positive phase but not after HBeAg seroconversion.Keywords
This publication has 13 references indexed in Scilit:
- Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype CGastroenterology, 2002
- Relationship of clinical and virological factors with hepatitis activity in hepatitis B e antigen‐negative chronic hepatitis B virus‐infected patientsJournal of Viral Hepatitis, 2002
- Genotypes and Clinical Phenotypes of Hepatitis B Virus in Patients with Chronic Hepatitis B Virus InfectionJournal of Clinical Microbiology, 2002
- Viral genotype and hepatitis B virus DNA levels are correlated with histological liver damage in HBeAg-negative chronic hepatitis B virus infectionThe American Journal of Gastroenterology, 2002
- Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in JapanJournal of Hepatology, 2001
- Genotype may correlate with liver carcinogenesis and tumor characteristics in cirrhotic patients infected with hepatitis B virus subtype adwJournal of Medical Virology, 2001
- Hepatitis B e antigen-negative chronic hepatitis b in Hong KongJournal of Hepatology, 2000
- Core Promoter Mutations and Genotypes in Relation to Viral Replication and Liver Damage in East Asian Hepatitis B Virus CarriersThe Journal of Infectious Diseases, 1999
- Genotypes, nt 1858 Variants, and Geographic Origin of Hepatitis B Virus—Large‐Scale Analysis Using a New Genotyping MethodThe Journal of Infectious Diseases, 1997
- Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infectionGastroenterology, 1987