Fasting blood glucose is independently associated with resting and exercise blood pressures and development of elevated blood pressure
- 1 July 2003
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal Of Hypertension
- Vol. 21 (7), 1383-1389
- https://doi.org/10.1097/00004872-200307000-00029
Abstract
Objective To assess whether fasting blood glucose is independently related to blood pressure at rest and during exercise, and to development of elevated blood pressure. Design Cross-sectional and prospective cohort study of 2014 apparently healthy middle-aged men. Methods The baseline survey included carefully standardized blood pressure measurements at rest and during exercise testing, an intravenous glucose tolerance test and a panel of fasting blood tests, including fasting blood glucose. Results from 7-years follow-up provided data on development of elevated blood pressure. Results Strong associations were found between quartiles of fasting blood glucose and baseline resting and/or exercise levels of blood pressure, and also development of elevated blood pressure over 7 years. Physical fitness, calculated from an exercise test, had a strong modulating effect on blood pressure at all levels of fasting blood glucose. In multivariate models – after adjusting for intravenous glucose tolerance, physical fitness, age, body mass index, triglycerides and cholesterol – fasting blood glucose was strongly associated with blood pressure at rest (coefficient = 2.83, P = 0.0004) and during exercise (coefficient = 6.57, P< 0.0001), and further to development of treated hypertension and/or elevated blood pressure [odds ratio (OR), 1.17; 95% confidence interval (CI), 1.05–1.31]. Conclusion In healthy non-diabetic and non-hypertensive men, strong associations were found between fasting blood glucose and blood pressure at rest and during exercise and to development of elevated blood pressure after 7-years follow-up. Fasting glucose metabolism deserves scrutiny when studying the pathogenesis of hypertension.Keywords
This publication has 24 references indexed in Scilit:
- Fasting Versus Postload Glucose LevelsDiabetes Care, 2001
- Relation of Impaired Fasting and Postload Glucose With Incident Type 2 Diabetes in a Dutch PopulationJAMA, 2001
- Epidemiology of insulin resistance and its relation to coronary artery diseaseThe American Journal of Cardiology, 1999
- Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men.Diabetes Care, 1999
- Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO ConsultationDiabetic Medicine, 1998
- Report of the Expert Committee on the Diagnosis and Classification of Diabetes MellitusDiabetes Care, 1997
- Evidence-Based Health Policy—Lessons from the Global Burden of Disease StudyScience, 1996
- Clustering of cardiovascular risk factors in confirmed prehypertensive individuals.Hypertension, 1992
- Prospective analysis of the insulin-resistance syndrome (syndrome X)Diabetes, 1992
- Banting lecture 1988. Role of insulin resistance in human diseaseDiabetes, 1988