Inflammatory pathways in female reproductive health and disease
Top Cited Papers
- 1 December 2009
- journal article
- review article
- Published by Bioscientifica in Reproduction
- Vol. 138 (6), 903-919
- https://doi.org/10.1530/rep-09-0247
Abstract
Inflammation involves alterations to vascular and immune cell function. It is well recognised that many physiological reproductive events such as ovulation, menstruation, implantation and onset of labour display hallmark signs of inflammation. These are orchestrated by specific molecular pathways involving a host of growth factors, cytokines, chemokines and lipid mediators. Resumption of normal reproductive function involves prompt and proper resolution of these inflammatory pathways. Recent literature confirms that resolution of inflammatory pathways involves specific biochemical events that are activated to re-establish homeostasis in the affected tissue. Moreover, initiation and maintenance of inflammatory pathways are the key components of many pathologies of the reproductive tract and elsewhere in the body. The onset of reproductive disorders or disease may be the result of exacerbated activation and maintenance of inflammatory pathways or their dysregulated resolution. This review will address the role of inflammatory events in normal reproductive function and its pathologies. Reproduction (2009) 138 903-919Keywords
This publication has 141 references indexed in Scilit:
- Leukocytes are primed in peripheral blood for activation during term and preterm labourMolecular Human Reproduction, 2009
- Papillomaviruses in the causation of human cancers — a brief historical accountVirology, 2009
- Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2Human Reproduction, 2008
- Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediatorsNature Reviews Immunology, 2008
- Stress and reproductive failure: past notions, present insights and future directionsJournal of Assisted Reproduction and Genetics, 2008
- F-prostanoid receptor alters adhesion, morphology and migration of endometrial adenocarcinoma cellsOncogene, 2007
- Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruationHuman Reproduction, 2007
- Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signatureAmerican Journal of Obstetrics and Gynecology, 2006
- The emerging role of lysophosphatidic acid in cancerNature Reviews Cancer, 2003
- Inflammation and cancerNature, 2002