Inflammation and cancer
Top Cited Papers
- 19 December 2002
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 420 (6917), 860-867
- https://doi.org/10.1038/nature01322
Abstract
Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.Keywords
This publication has 80 references indexed in Scilit:
- Chemokines: agents for the immunotherapy of cancer?Nature Reviews Immunology, 2002
- New functions for the matrix metalloproteinases in cancer progressionNature Reviews Cancer, 2002
- The role of chemoattraction in cancer metastasesBioEssays, 2001
- The role of STATs in transcriptional control and their impact on cellular functionOncogene, 2000
- The Biology of Chemokines and their ReceptorsAnnual Review of Immunology, 2000
- The Hallmarks of CancerCell, 2000
- The Functional Role of the ELR Motif in CXC Chemokine-mediated AngiogenesisOnline Journal of Public Health Informatics, 1995
- Neutrophils Express Tumor Necrosis Factor-α During Mouse Skin Wound HealingJournal of Investigative Dermatology, 1995
- Tumors: Wounds That Do Not HealThe New England Journal of Medicine, 1986
- THE EXPERIMENTAL DISCLOSURE OF LATENT NEOPLASTIC CHANGES IN TARRED SKINThe Journal of Experimental Medicine, 1941