Lanthanide-based luminescence biolabelling
- 12 February 2016
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 52 (29), 5080-5095
- https://doi.org/10.1039/c6cc00922k
Abstract
Luminescent lanthanide complexes display unrivalled spectroscopic properties, which place them in a special category in the luminescent toolbox. Their long-lived line-like emission spectra are the cornerstones of numerous analytical applications ranging from ultrasensitive homogeneous fluoroimmunoassays to the study of molecular interactions in living cells with multiplexed microscopy. However, achieving such minor miracles is a result of years of synthetic efforts and spectroscopic studies to understand and gather all the necessary requirements for the labels to be efficient. This feature article intends to survey these criteria and to discuss some of the most important examples reported in the literature, before explaining in detail some of the applications of luminescent lanthanide labels to bioanalysis and luminescence microscopy. Finally, the emphasis will be put on some recent applications that hold great potential for future biosensing.Keywords
This publication has 193 references indexed in Scilit:
- A Single Sensitizer for the Excitation of Visible and NIR Lanthanide Emitters in Water with High Quantum YieldsAngewandte Chemie-International Edition, 2012
- Octadentate Cages of Tb(III) 2-Hydroxyisophthalamides: A New Standard for Luminescent Lanthanide LabelsJournal of the American Chemical Society, 2011
- Lanthanide-based time-resolved luminescence immunoassaysAnalytical and Bioanalytical Chemistry, 2011
- Time-resolved luminescence resonance energy transfer imaging of protein–protein interactions in living cellsProceedings of the National Academy of Sciences of the United States of America, 2010
- Monitoring a Coordinated Exchange Process in a Four-Component Biological Interaction System: Development of a Time-Resolved Terbium-Based One-Donor/Three-Acceptor Multicolor FRET SystemJournal of the American Chemical Society, 2010
- Second window for in vivo imagingNature Nanotechnology, 2009
- A dual-acceptor time-resolved Föster resonance energy transfer assay for simultaneous determination of thyroid hormone regulation of corepressor and coactivator binding to the thyroid hormone receptor: Mimicking the cellular context of thyroid hormone actionAnalytical Biochemistry, 2009
- Lanthanide‐Based Conjugates as Polyvalent Probes for Biological LabelingEuropean Journal of Inorganic Chemistry, 2008
- Bright Ideas for Chemical BiologyACS Chemical Biology, 2008
- Time-Resolved Analysis of a Highly Sensitive Förster Resonance Energy Transfer Immunoassay Using Terbium Complexes as Donors and Quantum Dots as AcceptorsJournal of Biomedicine and Biotechnology, 2007