How well does ASPECTS predict the outcome of acute stroke treated with IV tPA?
- 8 August 2006
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 67 (3), 516-518
- https://doi.org/10.1212/01.wnl.0000228221.44334.73
Abstract
The authors measured the association of early ischemic change on CT scan, measured using the Alberta Stroke Programme Early CT score (ASPECTS), and functional outcome in 825 patients with anterior circulation stroke treated with IV thrombolysis within 3 hours of onset. ASPECTS predicted outcome in a graded fashion (linearly for ASPECTS 6 through 10; pattern ill-defined for ASPECTS 0 through 5) but discriminated individual outcomes weakly. Except perhaps when early ischemic change is extensive, clinicians should not estimate prognosis using ASPECTS alone.This publication has 9 references indexed in Scilit:
- Importance of Early Ischemic Computed Tomography Changes Using ASPECTS in NINDS rtPA Stroke StudyStroke, 2005
- Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness StudyCMAJ : Canadian Medical Association Journal, 2005
- Guidelines for the Early Management of Patients With Ischemic StrokeStroke, 2005
- Improving the Predictive Accuracy of Recanalization on Stroke Outcome in Patients Treated With Tissue Plasminogen ActivatorStroke, 2004
- Lack of Clinical Significance of Early Ischemic Changes on Computed Tomography in Acute StrokeJAMA, 2001
- Predictors of good outcome after intravenous tPA for acute ischemic strokeNeurology, 2001
- Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapyThe Lancet, 2000
- Tissue Plasminogen Activator for Acute Ischemic StrokeThe New England Journal of Medicine, 1995
- The meaning and use of the area under a receiver operating characteristic (ROC) curve.Radiology, 1982