Lack of Clinical Significance of Early Ischemic Changes on Computed Tomography in Acute Stroke

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Abstract
In patients with acute ischemic stroke treated with recombinant tissue plasminogen activator (rt-PA) within 3 hours of stroke onset, the National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group reported a highly statistically significant therapeutic effect at 3 months,1 which was sustained at 1 year.2