Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms
- 1 June 1987
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 66 (6), 865-874
- https://doi.org/10.3171/jns.1987.66.6.0865
Abstract
✓ Forty patients with previously untreated intracranial glial neoplasms underwent stereotaxic serial biopsies assisted by computerized tomography (CT) and magnetic resonance imaging (MRI). Tumor volumes defined by computer reconstruction of contrast enhancement and low-attenuation boundaries on CT and T1 and T2 prolongation on MRI revealed that tumor volumes defined by T2-weighted MRI scans were larger than those defined by low-attenuation or contrast enhancement on CT scans. Histological analysis of 195 biopsy specimens obtained from various locations within the volumes defined by CT and MRI revealed that: 1) contrast enhancement most often corresponded to tumor tissue without intervening parenchyma; 2) hypodensity corresponded to parenchyma infiltrated by isolated tumor cells or in some instances to tumor tissue in low-grade gliomas or to simple edema; and 3) isolated tumor cell infiltration extended at least as far as T2 prolongation on magnetic resonance images. This information may be useful in planning surgical procedures and radiation therapy in patients with intracranial glial neoplasms.Keywords
This publication has 22 references indexed in Scilit:
- Transposition of volumetric information derived from computed tomography scanning into stereotactic spaceSurgical Neurology, 1984
- Computer Simulation for the Stereotactic Placement of Interstitial Radionuclide Sources into Computed Tomography-defined Tumor VolumesNeurosurgery, 1984
- Brachytherapy of recurrent malignant brain tumors with removable high-activity iodine-125 sourcesJournal of Neurosurgery, 1984
- Correlations between cytologic composition and biologic behavior in the glioblastoma multiforme. A postmortem study of 50 casesCancer, 1983
- Computerized tomographic and pathologic studies of the untreated, quiescent, and recurrent glioblastoma multiformeJournal of Neurosurgery, 1983
- Effect of Dexamethasone Treatment on Peritumoral Brain EdemaJournal of Computer Assisted Tomography, 1982
- Histologic factors of prognostic significance in the glioblastoma multiformeCancer, 1980
- Assumptions in the radiotherapy of glioblastomaNeurology, 1980
- Gemistocytic Astrocytes in GliomasJournal of Neuropathology and Experimental Neurology, 1975
- A radioautographic study of a human brain and glioblastoma multiforme after the in vivo uptake of tritiated thymidineCancer, 1960