Soymetide, an immunostimulating peptide derived from soybean β‐conglycinin, is an fMLP agonist
- 20 March 2003
- journal article
- Published by Wiley in FEBS Letters
- Vol. 540 (1-3), 206-210
- https://doi.org/10.1016/s0014-5793(03)00265-5
Abstract
A tridecapeptide (MITLAIPVNKPGR) that stimulates phagocytosis of human neutrophils was isolated from a trypsin digest of soybean proteins. This peptide is derived from the soybean beta-conglycinin alpha' subunit and was named soymetide-13. The N-terminal methionine residue of soymetide-13 is essential for its activity, and removal of C-terminal residues revealed that soymetide-4 (MITL) is the minimal structure required for phagocytosis stimulation. Although they are not formylated at their N-termini, soymetides have a weak affinity for the N-formyl-methionyl-leucyl-phenylalanine (fMLP) receptor and their phagocytosis-stimulating activity is inhibited by the fMLP antagonist Boc-MLP. Interestingly, soymetide-4 promotes tumor necrosis factor alpha production at a higher level than soymetide-13 following oral administration in mice.Keywords
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