The psychological impact of mild ovarian stimulation combined with single embryo transfer compared with conventional IVF
Open Access
- 25 November 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 21 (3), 721-727
- https://doi.org/10.1093/humrep/dei395
Abstract
BACKGROUND: The objective of this study was to assess the psychological implications of mild ovarian stimulation combined with single embryo transfer (SET) during a first IVF cycle. METHODS: We conducted a randomized controlled two-centre trial. Three hundred and ninety-one couples were randomized to undergo either mild ovarian stimulation with GnRH antagonist co-treatment and SET (n = 199) or conventional GnRH agonist long protocol ovarian stimulation with double embryo transfer (DET) (n = 192). Women completed the Hospital Anxiety and Depression Scale, the Hopkins Symptom Checklist and the Subjective Sleep Quality Scale at baseline, on the first day of ovarian stimulation and following embryo transfer. Affect was assessed daily with the Daily Record Keeping Chart from the first day of ovarian stimulation until the day treatment outcome became known. RESULTS: The conventional IVF group experienced elevated levels of physical and depressive symptoms during pituitary downregulation. At oocyte retrieval, this group experienced more positive affect and less negative affect than the mild IVF group. In the conventional IVF group, cycle cancellation was associated with less positive and more negative affect. CONCLUSIONS: During the first IVF treatment cycle, mild ovarian stimulation and SET does not lead to more psychological complaints than conventional IVF.Keywords
This publication has 28 references indexed in Scilit:
- Why is the clinical acceptance of gonadotropin-releasing hormone antagonist cotreatment during ovarian hyperstimulation for in vitro fertilization so slow?Fertility and Sterility, 2005
- Multiple birth resulting from ovarian stimulation for subfertility treatmentThe Lancet, 2005
- Effectiveness of a psychosocial counselling intervention for first-time IVF couples: a randomized controlled trialHuman Reproduction, 2005
- Headaches in Women Undergoing in Vitro Fertilization and Embryo‐Transfer TreatmentHeadache: The Journal of Head and Face Pain, 2005
- The desire for multiple pregnancy in male and female infertility patientsHuman Reproduction, 2004
- Review of clinical course and treatment of ovarian hyperstimulation syndrome (OHSS)Human Reproduction Update, 2003
- Minimal ovarian stimulation for IVF: appraisal of potential benefits and drawbacksHuman Reproduction, 1999
- Chronic GnRH agonist administration down-regulates platelet serotonin transporter in women undergoing assisted reproductive treatmentPsychopharmacology, 1996
- Impact of the in-vitro fertilization process on emotional, physical and relational variablesHuman Reproduction, 1996
- The Hopkins Symptom Checklist (HSCL): A self-report symptom inventoryBehavioral Science, 1974