Headaches in Women Undergoing in Vitro Fertilization and Embryo‐Transfer Treatment
- 4 March 2005
- journal article
- Published by Wiley in Headache: The Journal of Head and Face Pain
- Vol. 45 (3), 215-219
- https://doi.org/10.1111/j.1526-4610.2005.05047.x
Abstract
In vitro fertilization and embryo transfer has become a common therapeutic modality in modern fertility medicines. Treatment protocols are associated with exaggerated hormonal fluctuations in order to promote multiple follicular development and support of embryo survival. Estrogen is considered to be closely linked to migraine, and its extreme serum level fluctuations have been considered to trigger migrainous headaches. To assess the prevalence, nature, and timing of headache attacks during the course of in vitro fertilization and embryo-transfer treatments. We retrospectively evaluated the prevalence and the characteristics of headache among 98 women undergoing in vitro fertilization and embryo transfer therapy using a structured telephone interview. Out of the 98 evaluated patients 25 were migraine sufferers. Headache attacks during the in vitro fertilization and embryo transfer protocol were reported by 28.6% (n = 28) of the women and were significantly more prevalent among the migraineurs. The attacks were of debilitating severity in 82% (n = 23) of patients who reported headaches during treatment. Headache occurred most frequently following gonadotropin-releasing hormone (GnRH) analog induced hypothalamic-pituitary-ovarian axis downregulation, typically associated with very low 17-beta-estradiol (17-beta-E2) serum level. In vitro fertilization and embryo-transfer treatment might be associated with various degrees of headache. This is mostly observed in patients with migraine headache background and specifically during the downregulation stage of treatment, when very low levels of 17-beta-E2 are observed. (Headache 2005;45:215-219).Keywords
This publication has 8 references indexed in Scilit:
- Oestrogen and attacks of migraine with and without auraThe Lancet Neurology, 2004
- Progress we can be proud of: U.S. trends in assisted reproduction over the first 20 yearsFertility and Sterility, 2002
- Race and assisted reproduction: A case-controlled study of outcomes in African-American and Caucasian womenFertility and Sterility, 2002
- Physiology of the Menstrual CycleCephalalgia, 2000
- Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factorsPublished by American Medical Association (AMA) ,1992
- Estrogens, progestins, and headacheNeurology, 1991
- The Role of Estrogen in Migraine: A Review and HypothesisCephalalgia, 1984
- MIGRAINE AND REPRODUCTIVE HORMONES THROUGHOUT THE MENSTRUAL CYCLEThe Lancet, 1975