Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football
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Open Access
- 25 July 2017
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 318 (4), 360-370
- https://doi.org/10.1001/jama.2017.8334
Abstract
Quiz Ref ID Chronic traumatic encephalopathy (CTE) is a progressive neurodegeneration associated with repetitive head trauma.1-8 In 2013, based on a report of the clinical and pathological features of 68 men with CTE (including 36 football players from the current study), criteria for neuropathological diagnosis of CTE and a staging scheme of pathological severity were proposed.6 Two clinical presentations of CTE were described; in one, the initial features developed at a younger age and involved behavioral disturbance, mood disturbance, or both; in the other, the initial presentation developed at an older age and involved cognitive impairment.9 In 2014, a methodologically rigorous approach to assessing clinicopathological correlation in CTE was developed using comprehensive structured and semistructured informant interviews and online surveys conducted by a team of behavioral neurologists and neuropsychologists.10 In 2015, the neuropathological criteria for diagnosis of CTE were refined by a panel of expert neuropathologists organized by the National Institute of Neurological Disorders and Stroke and the National Institute of Biomedical Imaging and Bioengineering (NINDS-NIBIB).8Keywords
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