Injectable Poly-l-Lactic Acid
- 1 February 2009
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Dermatologic Surgery
- Vol. 35 (Sup 1), 344-349
- https://doi.org/10.1111/j.1524-4725.2008.01061.x
Abstract
Injectable poly-l-lactic acid (PLLA) has been used to correct age- or disease-related facial volume deficits. This single-center, retrospective survey evaluated PLLA for cosmetic use. A questionnaire was mailed to 281 patients treated with PLLA 6 months or more previously. PLLA was reconstituted 4 hours or more before injection with 5 mL of sterile water plus 1 mL of 1% xylocaine added before injection. Two hundred twenty-one patients responded (210 female; average age 54.3; average treatments 3.3 per patient); the majority had received facial injections. Transient side effects included bruising, swelling, and discomfort. After treatment (1-6 months), 14/41 patients developed Grade 1 papules or nodules (slightly palpable, nonvisible; clinically nonrelevant; all resolved spontaneously), 15/41 developed Grade 2 papules or nodules (palpable, slightly visible; clinically nonrelevant; all resolved spontaneously), and 12/41 developed Grade 3 nodules (easily palpable, obviously visible [9 perioral; 3 periorbital or temple]; 5 resolved spontaneously; 7 were treated [5 intralesional corticosteroids; 2 surgery]). Patients treated with PLLA experienced duration of improvement of up to 24 months. Maximum improvement took several treatment sessions. Nodules occurred in perioral and periorbital regions, so incidence is reduced by avoiding these areas.Keywords
This publication has 12 references indexed in Scilit:
- Soft-Tissue Augmentation and the Role of Poly-L-Lactic AcidPlastic and Reconstructive Surgery, 2006
- Injectable Poly-L-Lactic Acid (Sculptra): Technical Considerations in Soft-Tissue ContouringPlastic and Reconstructive Surgery, 2006
- Poly-L-lactic acid for treating HIV-associated facial lipoatrophy: a review of the clinical studiesInternational Journal of STD & AIDS, 2006
- Poly-l-lactic acid: consultation on the injection techniquesJournal of the European Academy of Dermatology and Venereology, 2006
- Dispelling the myth: appropriate use of poly‐l‐lactic acid and clinical considerationsJournal of the European Academy of Dermatology and Venereology, 2006
- Adverse Reactions to Dermal FillersDermatologic Surgery, 2005
- Deep Subcutaneous Application of Poly-L-Lactic Acid as a Filler for Facial Lipoatrophy in HIV-Infected PatientsSkin Pharmacology and Physiology, 2005
- Assessment of the safety and efficacy of poly-L-lactic acid for the treatment of HIV-associated facial lipoatrophyJournal of the American Academy of Dermatology, 2005
- Safety of Sculptra®: a review of clinical trial dataJournal of Cosmetic and Laser Therapy, 2005
- Tissue response and in vivo degradation of selected polyhydroxyacids: Polylactides (PLA), poly(3‐hydroxybutyrate) (PHB), and poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHB/VA)Journal of Biomedical Materials Research, 1993