Adverse Reactions to Dermal Fillers
- 1 November 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Dermatologic Surgery
- Vol. 31 (s4), 1626-1633
- https://doi.org/10.2310/6350.2005.31250
Abstract
Background. For many patients, injectable filling agents offer the promise of facial rejuvenation while offering reduced risks compared with more invasive surgery. With the increase in products available and the rise in the number of patients seeking this type of intervention, it is crucial that both the physician and the patient are fully cognizant of the risks involved with each product. Objective. To review the incidences and types of reaction to various commonly used injectable products. Methods. A literature review and personal experiences (gained largely in Europe over the past 8 years) of dermal fillers from 1996 to the present, including illustrative case reviews. Results. Reactions can be attributed to the procedure itself, the procedural technique, and the agent injected. Some of these reactions are preventable, whereas others are inevitable; most are mild and transient. Improving product formulations, altering the concentration of product injected, or changing the injection technique can dramatically reduce the incidence of adverse reactions. Since its reformulation in mid‐1999, the biologically engineered hyaluronic acid filler Restylane (Medicis Pharmaceuticals, Scottsdale, AZ, USA) elicits less than one allergic reaction in 1,600 treatments. Skin reactions with poly‐l‐lactic acid (New‐Fill/Sculptra, Dermik Laboratories, Berwyn, PA, USA) are considerably less likely if a greater dilution and deeper injection technique are employed. Conclusion. Different injectable products have highly divergent properties, associated risks, and injection requirements. The dermasurgeon should be suitably experienced to select and use these products correctly.Keywords
This publication has 24 references indexed in Scilit:
- Botox and Collagen for Glabellar FurrowsAnnals of Plastic Surgery, 2004
- Comparison of resorbable soft tissue fillersAesthetic Surgery Journal, 2004
- Lumps and Bumps:Plastic and Reconstructive Surgery, 2003
- Polylactic acid implants (New-Fill)® to correct facial lipoatrophy in HIV-infected patientsAIDS, 2003
- When and how to combine treatmentsPublished by Taylor & Francis Ltd ,2002
- The Value of a New Filler Material in Corrective and Cosmetic Surgery: DermaLive and DermaDeepAesthetic Plastic Surgery, 2001
- Allergic reactions to oral, surgical and topical bovine collagen: Anaphylactic risk for surgeonsAustralian and New Zealand Journal of Ophthalmology, 1996
- Abscess formation and local necrosis after treatment with Zyderm or Zyplast Collagen ImplantJournal of the American Academy of Dermatology, 1991
- A comparative study of the biologic and immunologic response to medical devices derived from dermal collagenJournal of Biomedical Materials Research, 1986
- Injectable collagen implant—updateJournal of the American Academy of Dermatology, 1983