Regulation of chronic inflammatory and immune processes by extracellular vesicles
Open Access
- 1 April 2016
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 126 (4), 1173-1180
- https://doi.org/10.1172/jci81131
Abstract
Almost all cell types release extracellular vesicles (EVs), which are derived either from multivesicular bodies or from the plasma membrane. EVs contain a subset of proteins, lipids, and nucleic acids from the cell from which they are derived. EV factors, particularly small RNAs such as miRNAs, likely play important roles in cell-to-cell communication both locally and systemically. Most of the functions associated with EVs are in the regulation of immune responses to pathogens and cancer, as well as in regulating autoimmunity. This Review will focus on the different modes of immune regulation, both direct and indirect, by EVs. The therapeutic utility of EVs for the regulation of immune responses will also be discussed.Keywords
This publication has 104 references indexed in Scilit:
- The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle‐associated immune complexesEMBO Molecular Medicine, 2012
- Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activityMatrix Biology, 2012
- The MSC: An Injury DrugstoreCell Stem Cell, 2011
- Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cellsNature Communications, 2011
- Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infectionNature, 2011
- Tumour microvesicles contain retrotransposon elements and amplified oncogene sequencesNature Communications, 2011
- Induction of pregnancy during established EAE halts progression of CNS autoimmune injury via pregnancy-specific serum factors☆Journal of Neuroimmunology, 2010
- B7‐1/2, but not PD‐L1/2 molecules, are required on IL‐10‐treated tolerogenic DC and DC‐derived exosomes for in vivo functionEuropean Journal of Immunology, 2009
- Therapeutic effect of exosomes from indoleamine 2,3‐dioxygenase–positive dendritic cells in collagen‐induced arthritis and delayed‐type hypersensitivity disease modelsArthritis & Rheumatism, 2009
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007