Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
- 1 June 1985
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 315 (6021), 641-647
- https://doi.org/10.1038/315641a0
Abstract
Two distinct but distantly related complementary DNA [cDNA] encoding proteins sharing human interleukin 1 (IL-1) activity (termed IL-1.alpha. and IL-1.beta.) were isolated from a macrophage cDNA library. The primary translation products of the genes were 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produced IL-1 biological activity. [The effect of gene controlon IL expression in immunity and inflamation was mentioned.].This publication has 46 references indexed in Scilit:
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