Diagnosis of antiretroviral therapy failure in Malawi: poor performance of clinical and immunological WHO criteria
- 11 August 2009
- journal article
- research article
- Published by Wiley in Tropical Medicine & International Health
- Vol. 14 (8), 856-861
- https://doi.org/10.1111/j.1365-3156.2009.02309.x
Abstract
In antiretroviral therapy (ART) scale-up programmes in sub-Saharan Africa viral load monitoring is not recommended. We wanted to study the impact of only using clinical and immunological monitoring on the diagnosis of virological ART failure under routine circumstances. Clinicians in two urban ART clinics in Malawi used clinical and immunological monitoring to identify adult patients for switching to second-line ART. If patients met clinical and/or immunological failure criteria of WHO guidelines and had a viral load 200 cells/microl [OR = 5.03 (2.05, 12.34)]. Active tuberculosis and Kaposi's sarcoma were the most common conditions causing misclassification of virological ART failure. Misclassification of virological ART failure occurs frequently using WHO clinical and immunological criteria of ART failure for poor settings. A viral load test confirming virological ART failure is therefore advised to avoid unnecessary switching to second-line regimens.Keywords
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