ElliPro: a new structure-based tool for the prediction of antibody epitopes
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Open Access
- 2 December 2008
- journal article
- Published by Springer Science and Business Media LLC in BMC Bioinformatics
- Vol. 9 (1), 514
- https://doi.org/10.1186/1471-2105-9-514
Abstract
Reliable prediction of antibody, or B-cell, epitopes remains challenging yet highly desirable for the design of vaccines and immunodiagnostics. A correlation between antigenicity, solvent accessibility, and flexibility in proteins was demonstrated. Subsequently, Thornton and colleagues proposed a method for identifying continuous epitopes in the protein regions protruding from the protein's globular surface. The aim of this work was to implement that method as a web-tool and evaluate its performance on discontinuous epitopes known from the structures of antibody-protein complexes.Keywords
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