Correlation between segmental mobility and the location of antigenic determinants in proteins
- 1 September 1984
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 311 (5982), 123-126
- https://doi.org/10.1038/311123a0
Abstract
Most continuous antigenic determinants of tobacco mosaic virus protein (TMVP), myoglobin and lysozyme correspond to those surface regions in the protein structure, as determined by X-ray crystallography, which possess a run of high-temperature factors along the polypeptide backbone, that is, a high segmental mobility. The mobility of an antigenic determinant may make it easier to adjust to a pre-existing antibody site not fashioned to fit the exact geometry of a protein. The correlation found between temperature factors and antigenicity is better than that between hydrophilicity and antigenicity.Keywords
This publication has 49 references indexed in Scilit:
- How good are predictions of protein secondary structure?FEBS Letters, 1983
- A computer program for predicting protein antigenic determinantsMolecular Immunology, 1983
- Immunochemical studies of turnip yellow mosaic virus III. Localization of two viral epitopes in residues 57–64 and 183–189 of the coat proteinBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983
- Prediction of protein antigenic determinants from amino acid sequences.Proceedings of the National Academy of Sciences of the United States of America, 1981
- Structure and refinement of oxymyoglobin at 1·6 Å resolutionJournal of Molecular Biology, 1980
- A proposal for the nomenclature of antigenic sites in peptides and proteinsImmunochemistry, 1978
- Purification by immunoadsorption and immunochemical properties of histone H3FEBS Letters, 1977
- An immunological approach to the conformational equilibrium of staphylococcal nucleaseJournal of Molecular Biology, 1975
- The role of specific amino acid residues in the antigenic reactivity of the loop peptide of lysozymeImmunochemistry, 1973
- Preparation and properties of an artificial antigen immunologically related to tobacco mosaic virusBiochimica et Biophysica Acta, 1963