Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult
Open Access
- 11 February 2011
- journal article
- Published by Optica Publishing Group in Biomedical Optics Express
- Vol. 2 (3), 552-567
- https://doi.org/10.1364/boe.2.000552
Abstract
The near infrared spectroscopy (NIRS) frequency-domain multi-distance (FD-MD) method allows for the estimation of optical properties in biological tissue using the phase and intensity of radiofrequency modulated light at different source-detector separations. In this study, we evaluated the accuracy of this method to retrieve the absorption coefficient of the brain at different ages. Synthetic measurements were generated with Monte Carlo simulations in magnetic resonance imaging (MRI)-based heterogeneous head models for four ages: newborn, 6 and 12 month old infants, and adult. For each age, we determined the optimal set of source-detector separations and estimated the corresponding errors. Errors arise from different origins: methodological (FD-MD) and anatomical (curvature, head size and contamination by extra-cerebral tissues). We found that the brain optical absorption could be retrieved with an error between 8–24% in neonates and infants, while the error increased to 19–44% in adults over all source-detector distances. The dominant contribution to the error was found to be the head curvature in neonates and infants, and the extra-cerebral tissues in adults.Keywords
This publication has 44 references indexed in Scilit:
- Mesh-based Monte Carlo method using fast ray-tracing in Plücker coordinatesBiomedical Optics Express, 2010
- Noninvasive optical measures of CBV, StO2, CBF index, and rCMRO2 in human premature neonates' brains in the first six weeks of lifeHuman Brain Mapping, 2009
- Increased Cerebral Blood Volume and Oxygen Consumption in Neonatal Brain InjuryJournal of Cerebral Blood Flow & Metabolism, 2009
- Identifying Cortical Lateralization of Speech Processing in Infants Using Near-Infrared SpectroscopyDevelopmental Neuropsychology, 2009
- Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological explorationDevelopmental Science, 2008
- Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved systemJournal of Biomedical Optics, 2008
- Hemodynamic response to visual stimulation in newborn infants using functional near‐infrared spectroscopyHuman Brain Mapping, 2007
- Assessment of Infant Brain Development With Frequency-Domain Near-Infrared SpectroscopyPediatric Research, 2007
- Accuracy limits in the determination of absolute optical properties using time-resolved NIR spectroscopyMedical Physics, 2001
- Semi-infinite-geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximationJournal of the Optical Society of America B, 1994