Fractal dimension of chromatin is an independent prognostic factor for survival in melanoma
Open Access
- 5 June 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Cancer
- Vol. 10 (1), 260
- https://doi.org/10.1186/1471-2407-10-260
Abstract
Prognostic factors in malignant melanoma are currently based on clinical data and morphologic examination. Other prognostic features, however, which are not yet used in daily practice, might add important information and thus improve prognosis, treatment, and survival. Therefore a search for new markers is desirable. Previous studies have demonstrated that fractal characteristics of nuclear chromatin are of prognostic importance in neoplasias. We have therefore investigated whether the fractal dimension of nuclear chromatin measured in routine histological preparations of malignant melanomas could be a prognostic factor for survival.This publication has 51 references indexed in Scilit:
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